The fifth and final season of Brothers & Sisters premiered on September 26, 2010 and concluded May 8, 2011. Season five takes place one year after the events of the season four finale "On the Road Again". This season featured the show's 100th episode, with the airing of episode 13. The show stars Sally Field, Dave Annable, Rachel Griffiths, Calista Flockhart, Matthew Rhys, Ron Rifkin, Patricia Wettig, Luke Macfarlane, and Gilles Marini. The season was originally set to only feature 18 episodes to make way for new drama Off the Map in mid-season. However, on October 25, 2010, it was announced that ABC had picked up four more episodes, bringing the season to 22 episodes in total. The series' cancellation was announced on May 13, 2011.